Clin2
NCT06721520Likely a fitRecruiting

Botox vs. Pyloromyotomy for stomach drainage after esophageal surgery

Esophageal Cancer SurgeryEsophagectomyDelayed Gastric Emptying Following ProcedureEsophageal DiseasesEsophageal AchalasiaPylorus DysfunctionEsophageal Dysmotility

Treatments studied

Part of Digestive system clinical trials.

This trial compares two ways to help the stomach drain properly after surgery to remove part of the esophagus. One uses Botox injected into the stomach outlet, the other is a surgical cut of the muscle. The goal is to see which method works better at preventing stomach emptying problems.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
170 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • Age 18 or older
  • Having planned surgery to remove part or all of the esophagus (thoracoabdominal, Ivor-Lewis, or McKeown type)
  • Surgeon will use your stomach to reconnect the digestive tract
  • No conditions like ALS, muscular dystrophy, or myasthenia gravis (Botox would not be safe)
  • Not pregnant and no allergy to Botox
  • Able to attend follow-up visits and fill out surveys

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07814027Recruiting
Trial comparing two surgeries for achalasia

This trial compares two surgeries to treat achalasia, a condition where the esophagus fails to push food into the stomach. Both procedures aim to relax the muscle at the bottom of the esophagus, and the study will see which one works better for improving your symptoms.

Minya, Minya Governorate
NCT06870630Recruiting
Comparing two myotomy methods for type 2 achalasia

This trial tests two muscle-cutting procedures for people newly diagnosed with type 2 achalasia (a swallowing disorder). The goal is to see if a more complex myotomy works better than the standard one.

Hyderabad, Telangana
NCT05711758Recruiting
Endoscopic stomach muscle cut for weight loss

This trial tests whether an endoscopic procedure that cuts a stomach outlet muscle can help with weight loss and be safe. You would be screened to make sure you don’t have certain stomach, heart/lung, or pregnancy-related conditions that could make the procedure unsafe.

Boston, Massachusetts
NCT07220382Recruiting· Phase 4
Botox injections before large hernia surgery

This trial tests if getting Botox shots in the belly muscles before hernia surgery makes the repair easier and more successful. It is for adults who need a planned, open surgery for a large ventral hernia.

Cleveland, Ohio
NCT06556030Not yet recruiting· Phase 4
Early botox for closing the abdomen after surgery

This study tests whether giving Botox early helps close the abdomen after surgery when it was left open. The Botox is injected to relax the muscles, which may make it easier to close the wound later.

NCT04695600Recruiting· Phase 2/Phase 3
Botox for swallowing problems after brain injury

This trial tests if Botox injections in the throat can help people who have trouble swallowing due to a brain condition like stroke. It aims to improve safety and ease of eating and drinking.

New Delhi, National Capital Territory of Delhi

Hear when a new Esophagectomy trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.