Clinical trials
Esophagectomy clinical trials
Below are recruiting esophagectomy clinical trials, each written for real people, not researchers. We’re tracking 41 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05954702Recruiting
Tested added TRAM flap after esophagus surgery
This study looks at a surgical reconstructive technique (a “TRAM flap” made from tissue from the abdomen) during surgery for people with esophageal cancer who already had their esophagus removed. It aims to see whether this approach works better or more safely for rebuilding the food passage area.
São Paulo, São PauloAges 18 years+ - NCT05950438Recruiting
Study of outcomes after planned robotic esophagus surgery
This study looks at what happens after a planned (elective) robotic surgery to remove part or all of the esophagus. It may help doctors understand recovery and outcomes, and compare results among patients having this operation.
Chicago, IllinoisAges 18–89 - NCT00260559Recruiting
Checks quality of life after esophagus surgery
This study looks at outcomes and quality of life after esophagus removal surgery, comparing minimally invasive surgery and open surgery. It may help doctors understand how different surgical approaches affect how you feel during recovery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04135664RecruitingPhase 3
Compare surgery vs chemoradiation for early throat cancer
This study compares two ways to treat a type of esophagus cancer: surgical removal (esophagectomy) versus chemoradiation (chemo plus radiation). It is for people with early-stage findings where scans suggest no lymph node spread.
Nanchang, JiangxiAges 18–75 - NCT04973306RecruitingPhase 2/Phase 3
Chemo-immunotherapy before surgery versus chemo-radiation
This trial compares adding immunotherapy to standard chemo-radiation before surgery for locally advanced, operable esophageal squamous cell cancer. It aims to improve how well the tumor responds and whether patients do better after surgery.
ShanghaiAges 18–75 - NCT05547529RecruitingPhase 3
Chemo and radiation before surgery versus chemo alone for esophageal cancer
This trial studies whether adding radiation to chemotherapy before surgery works better for people with operable (resectable) squamous cell esophageal cancer. It aims to improve outcomes by comparing two different treatment plans before the operation.
MoscowAges 18–70 - NCT04652180Recruiting
Robot surgery versus open surgery for esophagus cancer
This trial compares robot-assisted surgery with the standard open chest operation to remove esophagus and nearby tissue. It may help you understand which approach works better and is safer for patients whose cancer can be surgically removed.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT06162767Recruiting
Surgery comparison for junction cancer
This trial compares two surgical techniques for treating a specific type of cancer at the junction of the stomach and esophagus. It aims to find which surgery offers better outcomes for patients.
Nanjing, JiangsuAges 18–80 - NCT07605481Recruiting
Managing Dumping Syndrome After Esophageal Cancer Surgery
This study looks at dumping syndrome—a condition where food moves too quickly from your stomach after esophageal cancer surgery—and tests ways to help manage its symptoms like sweating, dizziness, and abdominal discomfort.
Seoul, Gangnam-gu Irwon-Ro 81Ages 18 years+ - NCT07449208Recruiting
Esophagectomy leak risk registry study
This study follows people having surgery to remove part of the esophagus (esophagectomy) who are at higher risk for a leak where the esophagus is reconnected. The goal is to learn more about who develops leaks and how to prevent them.
Basking Ridge, New JerseyAges 18 years+ - NCT07434739Recruiting
Pain relief after minimally invasive esophagectomy: catheter vs. epidural
This study compares two ways to manage pain after minimally invasive esophagectomy: a paravertebral catheter (a small tube near the spine) versus epidural analgesia (a tube in the back). The goal is to see which method provides better pain relief with fewer side effects.
LilleAges 18 years+ - NCT07355374Recruiting
Balloon dilation during esophageal cancer surgery
This trial tests whether expanding a balloon inside the esophagus during keyhole surgery can reduce a serious complication called anastomotic leak. If you have esophageal cancer and are scheduled for a minimally invasive Ivor Lewis esophagectomy, you may be eligible.
Basel, Canton of Basel-CityAges 18 years+ - NCT07309991Recruiting
Oxygen Levels After Esophageal Cancer Surgery and Healing Complications
This study looks at whether low oxygen levels in the blood after esophageal cancer surgery increases the risk of problems with how the surgery heals. By understanding this connection, doctors may be able to better prevent or treat healing complications.
Guangzhou, GuangdongAges 18–80 - NCT06721520RecruitingPhase 2/Phase 3
Botox vs. Pyloromyotomy for stomach drainage after esophageal surgery
This trial compares two ways to help the stomach drain properly after surgery to remove part of the esophagus. One uses Botox injected into the stomach outlet, the other is a surgical cut of the muscle. The goal is to see which method works better at preventing stomach emptying problems.
Cleveland, OhioAges 18 years+ - NCT05327517Recruiting
Surgery or chemo-radiation for cervical esophagus cancer
This study compares two ways to treat cervical esophagus squamous cell cancer: surgery alone versus chemo-radiation (chemotherapy plus radiation). It may help find the best approach to control the cancer while keeping side effects manageable.
BeijingAges 18–75 - NCT04306458Recruiting
Testing robot-assisted vs standard surgery for resectable esophageal cancer
This trial compares a robot-assisted approach to a standard minimally invasive approach for surgery in people with certain types of esophageal or gastroesophageal junction cancer that can be removed. It aims to see which surgery method works better and is safer for these patients.
MainzAges 18–90 - NCT03734952Recruiting
Radiation after esophagus surgery for stage II–III cancer
This study looks at whether giving radiation after surgery (after chemo and radiation before surgery) can improve outcomes for people with squamous cell esophagus cancer in the chest. You may be considered if you are well enough for treatment and your cancer has not spread.
Fuzhou, FujianAges 18–65 - NCT06136845Recruiting
Esophageal cancer microbiome and leak after surgery
This study looks at bacteria in esophageal cancer tumors and whether certain bacteria are linked to leaks that can happen after surgery to remove the esophagus. It may help doctors understand how to prevent these leaks in the future.
HaifaAges 18–85 - NCT07629817RecruitingPhase 3
Surgery vs. Chemoradiation for Esophageal Cancer
This trial compares surgery versus a strong combination of chemotherapy and radiation for people with esophageal squamous cell carcinoma that has been treated first with immunotherapy. It aims to find which approach leads to better outcomes after the initial immunotherapy and chemotherapy.
Zhengzhou, HenanAges 18–75 - NCT07567716Enrolling by invitation
Study of How Advanced Esophageal Cancer Spreads After Surgery
This research examines tissue samples from patients who had surgery to remove advanced esophageal cancer in the neck or chest area. The study aims to understand how the cancer invaded surrounding tissues, which may help doctors better treat similar patients in the future.
ShanghaiAges Any age - NCT07519486RecruitingPhase 2
Nutrition support during cancer treatment before surgery
This trial tests whether intensive nutritional support helps patients with advanced esophageal cancer (a type of squamous cell carcinoma) respond better to treatment before surgery. The goal is to improve how well the cancer shrinks and prepare the body for a successful operation.
Chengdu, SichuanAges 18–80 - NCT07505186RecruitingPhase 2
Immunotherapy and chemotherapy before surgery for esophageal cancer
This trial tests a combination of an immunotherapy drug (camrelizumab), chemotherapy, and another targeted drug (ivarmacitinib) before surgery for esophageal cancer. The goal is to see if this treatment can shrink the tumor before it is removed, potentially improving outcomes.
Hangzhou, ChinaAges 18–75 - NCT02972372Recruiting
Compare chemoradiation with surgery for esophageal cancer
This study compares two treatment approaches for certain locally advanced esophageal cancers: chemoradiation (chemo plus radiation) versus esophagus surgery. It may help find which option works better to control the cancer and improve outcomes.
Anyang, HenanAges 18–75 - NCT02634645Recruiting
Treatment study for Barrett’s pre-cancer or esophageal cancer
This study looks at treatment options for people with Barrett’s esophagus that has progressed to abnormal cell growth (dysplasia) or cancer. It may help doctors compare approaches that use procedures to remove and/or destroy abnormal tissue in the esophagus.
Los Angeles, CaliforniaAges 18–100
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Common questions
- Are there clinical trials for esophagectomy?
- Yes. Clin2 currently lists 41 recruiting esophagectomy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a esophagectomy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a esophagectomy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.