Epcoritamab and lenalidomide for immunodeficiency-related lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of two drugs, epcoritamab and lenalidomide, for patients with a rare type of large B-cell lymphoma linked to a weakened immune system. It is for people whose lymphoma did not improve or returned after standard treatments, and who cannot get CAR-T therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a type of large B-cell lymphoma that is related to a weak immune system, such as from an organ transplant, an autoimmune disease, or an Epstein-Barr virus infection.
- Your lymphoma must not have responded to initial treatment or come back after treatment, and you must not be able to receive CAR-T cell therapy.
- You must be 18 years or older and in reasonably good health (able to do daily activities without major help).
- Your kidney and liver functions must be within certain ranges, and your blood counts (like neutrophils and platelets) must be high enough.
- If you are a woman who could become pregnant, you must use two effective birth control methods starting 30 days before treatment and for 12 months after.
- You cannot have had a prior treatment with a bispecific antibody targeting CD3 and CD20 (like epcoritamab) or have an active infection like uncontrolled HIV or hepatitis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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