Clin2
NCT06724952Possibly a fitNot yet recruiting

Silymarin supplement for rheumatoid arthritis with methotrexate

Rheumatoid Arthritis (RA)

Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.

This trial tests whether adding silymarin (a natural supplement from milk thistle) to standard methotrexate treatment can improve symptoms of rheumatoid arthritis. It may help reduce joint pain and swelling for people who are not yet in remission.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
44 people
Ages
18 years to 60 years
Study type
Interventional

Who can take part

  • You are between 18 and 60 years old
  • You have been diagnosed with active rheumatoid arthritis (not in remission)
  • You are currently taking methotrexate and other standard treatments
  • You do not have severe liver or kidney disease
  • You are not taking other antioxidant supplements
  • You are not pregnant or breastfeeding

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06641128Not yet recruiting· Phase 4
Empagliflozin with methotrexate for rheumatoid arthritis

This trial tests whether adding empagliflozin to methotrexate helps reduce rheumatoid arthritis activity compared to methotrexate alone. It may protect joints from further damage.

Al Mansurah
NCT07864688Not yet recruiting· Phase 2
Adding diabetes drugs to methotrexate for rheumatoid arthritis

This study tests whether two diabetes medications, dapagliflozin and empagliflozin, can help reduce rheumatoid arthritis symptoms when added to your current methotrexate treatment. It may offer a new option for people whose arthritis is still active despite methotrexate.

Cairo, Cairo Governorate
NCT07632846Recruiting· Phase 2
Roflumilast as add-on treatment for active rheumatoid arthritis

This study tests whether adding roflumilast, a new medication, to your current rheumatoid arthritis treatment can help reduce joint inflammation and improve your symptoms. You would take it alongside methotrexate, a common RA medication you may already be using.

Al Mansurah
NCT07745426Recruiting· Phase 2
Comparing add-on treatments for rheumatoid arthritis

This trial compares two additional medicines (diosmin or rebamipide) taken with standard arthritis treatment to see if they help reduce joint pain and swelling better than standard treatment alone.

Tanta
NCT06913907Recruiting· Phase 4
Methotrexate injection for new rheumatoid arthritis patients

This study tests a methotrexate injection (given under the skin) for people with moderate to severe rheumatoid arthritis who haven't taken methotrexate before. Researchers want to see how the medicine builds up in your body and if it helps control your symptoms.

Shinjuku-ku, Tokyo
NCT07463937Recruiting
Study of Methotrexate Injections in Rheumatoid Arthritis

This study looks at how well methotrexate injections work in people with rheumatoid arthritis. It is designed for patients who are starting or changing to this type of methotrexate treatment.

Beijing, Beijing Municipality

Hear when a new Rheumatoid Arthritis (RA) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.