Psilocybin for depression that hasn't responded to treatment in autistic adults
Treatments studied
Part of Mental health clinical trials.
This trial tests whether a single dose of psilocybin can help treat depression in autistic adults who have not gotten better with standard antidepressants. You will be asked to stop your current antidepressant and antipsychotic medications before the study, and you will have several follow-up visits and an MRI scan.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 65 years old
- Have a diagnosis of autism spectrum disorder and current major depressive disorder that has not improved after at least two adequate trials of antidepressants
- Be willing to stop your current antidepressant and antipsychotic medications for at least 2 weeks before the study starts
- Not have a history of psychosis, bipolar disorder, or a first-degree relative with these conditions
- Not use alcohol, cannabis, or other recreational drugs during the study period
- Have an IQ of 70 or higher, or score above the 10th percentile on a standard reasoning test
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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