Psilocybin for treatment-resistant depression brain imaging study
Treatments studied
Part of Mental health clinical trials.
This study tests whether a psilocybin-based treatment can help people with depression that has not improved after trying several antidepressants. You will receive the study treatment and have brain scans to see how it affects brain connections.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with major depression and have not responded to at least 2 different antidepressant treatments.
- You are willing to stop your current antidepressant and antipsychotic medications (with your doctor's approval) for 2 weeks or more before starting.
- You do not have a history of schizophrenia, bipolar disorder, or other serious mental health conditions (like psychosis).
- You have no medical condition that would make psilocybin unsafe, and you can safely undergo brain scans (MRI and PET).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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