Comparing two medications for early miscarriage care
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This trial compares two different medication approaches to help your body complete a silent miscarriage, rather than needing surgery. One uses a hormone-balancing pill (letrozole) and the other uses a combination of two medicines (mifepristone and misoprostol). The goal is to find which is more effective and safer for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with a silent miscarriage (a miscarriage where the pregnancy stops growing but your body hasn't expelled it yet) at 12 weeks of pregnancy or earlier.
- You have a single pregnancy sac in the uterus, not twins or more.
- You are not experiencing heavy vaginal bleeding or severe abdominal pain.
- You do not have signs of an infection in the uterus.
- You are not allergic to the study medicines: letrozole, mifepristone, or misoprostol.
- You are not taking medicines that could interact with mifepristone, such as aspirin, clopidogrel, or blood thinners.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking an aromatase inhibitor (letrozole) before misoprostol helps complete a miscarriage more effectively. It may offer a treatment option for people with a missed or early pregnancy loss.
This trial tests two different medicines (Mifepristone vs Misoprostol) to see which works better for ending a pregnancy in the second trimester (12–16 weeks). It is for people who are pregnant with one baby and have no major health issues that could affect safety.
This trial tests whether adding letrozole (a hormone pill) to misoprostol (a medicine to complete a miscarriage) works better than misoprostol alone for ending a missed miscarriage in early pregnancy. It aims to make the process safer and possibly faster.
This study compares two different medicines (given vaginally or by mouth) to help complete a miscarriage or missed abortion in the first weeks of pregnancy. It aims to find which method works better and is safer for women.
This study compares two different time intervals between taking two medications (mifepristone and misoprostol) to manage an early pregnancy loss (miscarriage). The goal is to find the best timing to help the body complete the miscarriage safely and effectively.
This study compares two medication combinations to see which is more effective for ending a pregnancy in the second trimester (14-20 weeks). It may help women who need this procedure have a safer and more successful experience.
Hear when a new Silent Miscarriage trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.