Using Letrozole and Misoprostol for Miscarriage Care
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This trial tests whether taking an aromatase inhibitor (letrozole) before misoprostol helps complete a miscarriage more effectively. It may offer a treatment option for people with a missed or early pregnancy loss.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed miscarriage (missed or anembryonic pregnancy).
- You are between 4 and 26 weeks pregnant (based on ultrasound).
- Your hemoglobin level is above 9 g/l (not severely anemic).
- Your cervix is closed with no pregnancy tissue in the canal.
- You have not tried to end this pregnancy before.
- You do not have certain health conditions like heart, kidney, or bleeding disorders, and your BMI is under 35.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding letrozole (a hormone pill) to misoprostol (a medicine to complete a miscarriage) works better than misoprostol alone for ending a missed miscarriage in early pregnancy. It aims to make the process safer and possibly faster.
This trial tests whether taking letrozole before misoprostol shortens the time needed to complete a missed abortion, which is when the pregnancy stops developing but the body hasn't expelled the tissue. If effective, it could reduce the waiting time and make the process more efficient.
This study compares two medications—letrozole plus misoprostol versus misoprostol alone—to see which is more effective for ending a pregnancy in the second trimester (14–20 weeks) after the fetus has stopped developing. The goal is to find a safer, more comfortable method for women who need this procedure.
This trial compares the effectiveness of two medications (letrozole and mifepristone with misoprostol) to help the body pass pregnancy tissue after a silent miscarriage. It may help women who prefer medical treatment over waiting or surgery.
This trial tests a medication called misoprostol to help the body expel pregnancy tissue after a fetal death between 18 and 24 weeks. It may be an option for women who have not had a previous C-section or have had only one.
This study compares two ways of taking medicine (by mouth or vaginal insertion) to safely manage a miscarriage that was discovered on ultrasound between 8–16 weeks of pregnancy. The goal is to see which method works better and causes fewer side effects.
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