Adding letrozole to standard miscarriage treatment
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This trial tests whether adding letrozole (a hormone pill) to misoprostol (a medicine to complete a miscarriage) works better than misoprostol alone for ending a missed miscarriage in early pregnancy. It aims to make the process safer and possibly faster.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are less than 13 weeks pregnant (based on your last period or ultrasound).
- You have a missed miscarriage (the pregnancy has stopped developing but your body hasn't passed the tissue yet).
- You are carrying only one baby (not twins or more).
- You have not had a cesarean section before.
- You have no scars on your uterus from previous surgeries or procedures.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This study is for women who have recently experienced a missed miscarriage (a pregnancy loss before 14 weeks where the baby stopped growing but did not leave the body). The goal is to learn more about why early pregnancy loss happens by doing careful tests and follow-ups.
This trial tests whether taking an aromatase inhibitor (letrozole) before misoprostol helps complete a miscarriage more effectively. It may offer a treatment option for people with a missed or early pregnancy loss.
This trial tests whether taking letrozole before misoprostol shortens the time needed to complete a missed abortion, which is when the pregnancy stops developing but the body hasn't expelled the tissue. If effective, it could reduce the waiting time and make the process more efficient.
This study compares two medications—letrozole plus misoprostol versus misoprostol alone—to see which is more effective for ending a pregnancy in the second trimester (14–20 weeks) after the fetus has stopped developing. The goal is to find a safer, more comfortable method for women who need this procedure.
This trial compares the effectiveness of two medications (letrozole and mifepristone with misoprostol) to help the body pass pregnancy tissue after a silent miscarriage. It may help women who prefer medical treatment over waiting or surgery.
This study tests whether taking letrozole or mifepristone before medication helps the medical abortion work better for pregnancies up to 10 weeks. You may be asked to try another method (repeat medicine or a procedure) if the first treatment does not fully work.
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