Adding letrozole to standard miscarriage treatment
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This trial tests whether adding letrozole (a hormone pill) to misoprostol (a medicine to complete a miscarriage) works better than misoprostol alone for ending a missed miscarriage in early pregnancy. It aims to make the process safer and possibly faster.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are less than 13 weeks pregnant (based on your last period or ultrasound).
- You have a missed miscarriage (the pregnancy has stopped developing but your body hasn't passed the tissue yet).
- You are carrying only one baby (not twins or more).
- You have not had a cesarean section before.
- You have no scars on your uterus from previous surgeries or procedures.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study is for women who have recently experienced a missed miscarriage (a pregnancy loss before 14 weeks where the baby stopped growing but did not leave the body). The goal is to learn more about why early pregnancy loss happens by doing careful tests and follow-ups.
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This study tests whether taking letrozole (a hormone-modifying drug) before misoprostol (a medication that helps empty the uterus) can shorten the time needed to complete a missed miscarriage. It may help make the process faster and more effective.
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This trial compares two different medication approaches to help your body complete a silent miscarriage, rather than needing surgery. One uses a hormone-balancing pill (letrozole) and the other uses a combination of two medicines (mifepristone and misoprostol). The goal is to find which is more effective and safer for you.
This study tests whether taking letrozole or mifepristone before medication helps the medical abortion work better for pregnancies up to 10 weeks. You may be asked to try another method (repeat medicine or a procedure) if the first treatment does not fully work.
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