Pulsed field ablation strategies for persistent atrial fibrillation
Part of Heart & circulation clinical trials.
This trial tests a new type of heart procedure called pulsed field ablation for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). It compares three different ways to use this ablation to try to restore a normal heart rhythm and reduce symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have been diagnosed with persistent atrial fibrillation (a long-lasting irregular heartbeat).
- You have tried at least one heart rhythm medication (like a beta blocker or calcium channel blocker) and it didn't work or caused side effects.
- You do not have severe heart valve disease that needs surgery.
- You do not have a blood clot in your left atrium (a heart chamber) seen on recent imaging.
- You have not had a recent heart attack, and your heart's pumping function is above 30%.
- You do not currently have a severe infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a new way to do a heart procedure (catheter ablation) for people with ongoing atrial fibrillation (an irregular heartbeat). It uses pulsed-field energy to create a block in the heart that stops abnormal electrical signals. The goal is to improve the procedure's success and reduce risks.
This trial tests a new way to treat non-paroxysmal atrial fibrillation (AF) using a focused type of ablation (pulsed-field energy) on specific areas of the heart. It aims to see if targeting the left atrial wall and mitral isthmus can improve outcomes for people who have not had this procedure before.
This trial tests a newer ablation technique called pulsed field ablation to treat atrial fibrillation, a heart rhythm disorder. The goal is to see if this method works well and is safe for patients who need treatment.
This study tests a newer, gentler way to fix irregular heartbeats in people with paroxysmal AF. The treatment uses special energy (pulsed fields) guided by 3D imaging to target the heart tissue causing the problem, and the goal is to restore a normal rhythm with fewer risks.
This trial compares two different ways of delivering pulsed field ablation—a newer, targeted energy that zaps abnormal heart tissue—for people with atrial fibrillation. It aims to see if a single broader application works as well as a more focused, two-step approach, and it may help you feel better if you have symptoms from this irregular heartbeat.
This study compares two procedures to treat persistent atrial fibrillation (an irregular heartbeat that lasts more than a week). It looks at whether a newer method (pulsed-field ablation) works better than the standard method (radiofrequency ablation), both combined with a chemical injection to improve treatment success.
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