Comparing two pulsed field ablation methods for atrial fibrillation
Part of Heart & circulation clinical trials.
This trial compares two different ways of delivering pulsed field ablation—a newer, targeted energy that zaps abnormal heart tissue—for people with atrial fibrillation. It aims to see if a single broader application works as well as a more focused, two-step approach, and it may help you feel better if you have symptoms from this irregular heartbeat.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have never had a heart ablation procedure for atrial fibrillation.
- You have symptomatic atrial fibrillation that is either paroxysmal (episodes come and go) or persistent (constant).
- For paroxysmal AF: you've had at least 2 episodes in the last 6 months and meet one of these: a CHA2DS2VA score of 2 or higher, or at least one cardioversion in the last 6 months, or an enlarged left atrium (≥45 mm).
- For persistent AF: you've had at least 1 episode in the last 6 months.
- You do not have atrial fibrillation caused by reversible conditions (like thyroid issues) or non-heart causes.
- You do not have severe mitral or tricuspid valve regurgitation that needs treatment.
- You are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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