Nasal spray before heart bypass to protect memory
Treatments studied
Part of Heart & circulation, Mental health clinical trials.
This study tests whether a nasal spray containing dexmedetomidine or insulin, given before heart bypass surgery, can help prevent memory and thinking problems that sometimes happen after the operation. It is for adults 60 and older.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 60 years old or older and scheduled for elective heart bypass surgery (on-pump).
- You do not have severe memory loss (score above 20 on a standard memory test).
- You do not have serious hearing, vision, or speech problems that could affect testing.
- You have not had recent nasal surgery (within 3 months) or major nasal conditions.
- You do not have severe sleep apnea or need a breathing machine after surgery.
- You do not drink alcohol heavily (score below 8 for men or 7 for women on a standard test).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if dexmedetomidine or methylprednisolone is better at reducing inflammation during coronary artery bypass grafting (CABG) with a heart-lung machine. The goal is to find a treatment that helps patients recover better.
This trial tests whether a nasal spray of dexmedetomidine can help control blood pressure in older adults with high blood pressure who are having cataract surgery. It may keep your blood pressure more stable during the procedure.
This trial tests if a medication called dexmedetomidine can help prevent postoperative delirium (sudden confusion and disorientation) after heart surgery. It is for adults having heart surgery with a heart-lung machine.
This study tests whether a nasal spray medicine (dexmedetomidine) can prevent confusion and delirium that sometimes occurs after lung surgery in people 65 and older. Delirium is temporary confusion that can happen after surgery; this trial investigates if this medication given through the nose may help reduce it.
This study tests if a calming medicine given as a nasal spray before a heart stent procedure can prevent heart muscle damage. It's for people with coronary artery disease who are scheduled for a planned stent procedure.
This trial tests a nasal spray (dexmedetomidine) given before breast-conserving surgery to help you stay calm and comfortable while awake during the procedure. It aims to improve your recovery and waking experience after surgery.
Hear when a new Post Operative Cognitive Dysfunction trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.