Combination therapy for KRAS G12C mutated colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a new drug combination (IBI351, cetuximab, and FOLFIRI) as first treatment or as a second treatment after standard chemotherapy for people with KRAS G12C mutated colorectal cancer that has spread. The goal is to see if it works well and is safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must have colorectal cancer that has spread to other parts of the body (stage IV).
- A special test must show your cancer has a specific mutation called KRAS G12C.
- You can join either as a first treatment or after your cancer has worsened on standard chemotherapy.
- You must be able to take oral medication and have normal organ function (like liver, kidney, blood).
- You must not have certain other cancers or unstable brain metastases.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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