Drug combination to treat muscle-invasive bladder cancer without bladder removal
Treatments studied
Part of Cancer, Kidney & urinary clinical trials.
This trial tests a combination of two drugs, enfortumab vedotin and pembrolizumab, to see if they can control muscle-invasive bladder cancer without needing to remove the bladder. It may be an option for people who want to try to preserve their bladder and avoid surgery or radiation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have bladder cancer that has grown into the muscle layer of the bladder wall, but has not spread to other parts of the body (this is called muscle-invasive bladder cancer).
- You must be healthy enough to receive the study drugs, with adequate blood counts, liver and kidney function.
- You must not have received prior chemotherapy or other systemic treatment (drugs that go throughout the body) for your bladder cancer.
- You must not have a serious autoimmune disease requiring treatment with steroids or immune-suppressing drugs in the last 2 years.
- You must agree to use effective birth control if there is any chance of pregnancy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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