Drug combination before surgery for invasive bladder or upper tract cancer
Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests a combination of two drugs (enfortumab vedotin and pembrolizumab) given before surgery to shrink or eliminate bladder or upper tract cancer. The goal is to see if this approach reduces the chance of cancer coming back and improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You can do most of your daily activities (performance status 0-2).
- For bladder cancer: the cancer has grown into the muscle layer but has not spread to other organs (stage T2 or higher, N0-N2, M0).
- For upper tract (kidney/ureter) cancer: your cancer is high-risk and you plan to have surgery.
- You have not had a live vaccine (like FluMist) in the last 30 days.
- You are not pregnant or breastfeeding, and you agree to use birth control if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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