Chemotherapy with or without heated chemo for advanced colon cancer
Part of Cancer, Digestive system clinical trials.
This trial tests if adding heated chemotherapy directly into the abdomen during surgery improves outcomes for people with advanced colon cancer that hasn't spread to other organs. It compares standard chemotherapy before surgery alone versus chemotherapy before surgery plus heated chemo during surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old (if 70-75, a committee will review your case).
- You have been diagnosed with colon, sigmoid colon, or rectum-sigmoid junction cancer that has grown through the bowel wall (T4a or T4b) or is high-risk with deeper invasion.
- The cancer has not spread to distant organs (like liver or lungs) based on CT or MRI scans.
- You are in good overall health and able to carry out daily activities (ECOG score 0 or 1).
- Your tumor shows a stable type of DNA repair (called pMMR or microsatellite stable).
- You have given written consent to participate.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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