Pain relief after knee replacement: injection methods compared
Part of Pain clinical trials.
This study compares two ways to give pain medicine during knee replacement surgery: one is injected into the bone, the other around the joint. Researchers want to see which works better and may help you recover with less pain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 50 and 80 years old.
- You are having a total knee replacement on one side only (not both knees at once).
- Your health status is classified as ASA 1, 2, or 3 (generally meaning you are in good to moderate health).
- You do not have severe kidney, liver, or blood problems, and have not had a seizure disorder, coronary heart disease, or recent blood clots.
- You have not used opioid pain medicines in the 5 days before surgery, and are not on blood thinners or anti-platelet medicines.
- You can understand and use a 0–10 pain scale (the 100mm VAS) and are willing to follow the study plan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two ways to manage pain after knee replacement surgery: a special nerve block (iPACK) versus a shot of medicine around the knee joint. The goal is to see which method gives better pain relief and helps you recover faster.
This study tests a long-lasting numbing medicine (liposomal bupivacaine) injected around the knee during total knee replacement surgery. It aims to see if this medicine helps control pain and reduce the need for other painkillers after surgery.
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
This study tests whether a special step-by-step numbing injection given before knee replacement surgery can provide better pain relief during and after the procedure. It may help you have less pain and use fewer painkillers after surgery.
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Hear when a new Total Knee Anthroplasty trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.