Clin2
NCT05279092Possibly a fitRecruiting

Testing two pain-control injections for knee replacement surgery

Total Knee ReplacementKnee Arthroplasty

Part of Bones, joints & muscles, Pain clinical trials.

This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
250 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are planning a first-time, one-sided knee replacement (for osteoarthritis) with spinal anesthesia
  • Your overall health status is fairly good (ASA class I, II, or III)
  • You can take part in follow-up by phone or online questionnaires after surgery
  • You are not pregnant
  • You do not have certain major bleeding or medical conditions that would stop use of the study medicines
  • You meet key safety checks (no severe liver/kidney disease, not very low body weight, and blood sugar is controlled)

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05736549Recruiting· Phase 2
Tested stronger pain-blocking shot for knee replacement surgery

This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.

New Haven, Connecticut
NCT07386600Recruiting
Comparing two drugs for knee replacement pain relief

This trial tests two different drugs (dexamethasone and dexmedetomidine) added to a standard nerve block for knee replacement. It aims to see which one provides better pain control after surgery.

Poznan
NCT06653621Not yet recruiting· Phase 4
Comparing two nerve blocks for knee replacement pain

This study tests two types of pain relief injections after total knee replacement to see which provides better pain control with fewer side effects. It compares a long-lasting liposome bupivacaine to standard bupivacaine, given in two different nerve block locations.

Wuhan, Hubei
NCT07677215Not yet recruiting
Knee replacement pain relief with extra nerve blocks and medicines

This study tests whether adding two types of nerve blocks plus two medicines can improve pain relief and recovery after knee replacement surgery. It may help patients have less pain and need fewer opioids.

Lublin
NCT07097493Not yet recruiting· Phase 4
Pain relief options after knee replacement surgery

This study compares two ways to manage pain after knee replacement surgery: one uses a long-lasting numbing medicine (liposomal bupivacaine), the other uses extra medicines alongside the numbing block. The goal is to find which approach gives better pain relief and helps you recover more comfortably.

Winston-Salem, North Carolina
NCT07584915Enrolling by invitation· Phase 4
Pain Relief Method Comparison for Knee Replacement Surgery

This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.

Los Angeles, California

Hear when a new Total Knee Replacement trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.