Clinical trials
Total Knee Anthroplasty clinical trials
Below are recruiting total knee anthroplasty clinical trials, each written for real people, not researchers. We’re tracking 13 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT07509866Recruiting
Comparing pain relief options for knee replacement surgery
This trial tests two different numbing medicines for knee replacement surgery. It compares a long-acting numbing medicine (liposomal bupivacaine) with a standard one (ropivacaine) mixed with other drugs to see which provides better pain control. The goal is to find a way to reduce pain and improve recovery.
Wuhan, HubeiAges 18–80 - NCT07454356Recruiting
Device to help knee bending after replacement
This study tests a non-surgical device called Knee Flexionater to help people who have limited knee bending after total knee replacement. The goal is to improve knee motion and avoid a second surgery.
Houston, TexasAges 40 years+ - NCT07366736Recruiting
Cold and compression after knee replacement – a study
This study tests if a cooling and compression device applied to the knee after replacement surgery helps with pain and recovery. It compares the device to standard care in people having their first knee replacement.
ÉchirollesAges 18 years+ - NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT06627699Recruiting
Study of the Freedom Total Knee System for knee replacement
This study is for people getting a total knee replacement for the first time. It looks at how well the Freedom Total Knee System works in everyday life.
Leawood, KansasAges 18 years+ - NCT06809998RecruitingPhase 1/Phase 2
Steroid injection in non-surgical knee before knee replacement
This study tests whether a single steroid injection in the healthy knee (the one not being replaced) can reduce pain and improve recovery after total knee replacement. It may help people who have arthritis in both knees but are only having one replaced now.
Toronto, OntarioAges 18 years+ - NCT07694895Recruiting
AI-assisted education for knee replacement recovery
This trial tests if an AI-powered educational video before you get up and walk after knee replacement surgery can help reduce fear of movement and make you feel more ready to leave the hospital.
Kocaeli, İzmitAges 18–100 - NCT07239258Recruiting
Tele-rehab plan for knee replacement recovery
This study tests a special therapy plan delivered through video calls to help people recover after knee replacement surgery. It compares telerehabilitation to in-person therapy to see if it improves pain and movement.
Lahore, Punjab ProvinceAges 50–65 - NCT07089251RecruitingPhase 4
Epinephrine and tranexamic acid in knee replacement surgery
This study tests if using epinephrine and tranexamic acid together helps reduce bleeding and improve outcomes during knee replacement surgery. It may be a good fit if you are planning to have knee replacement and do not have certain medical conditions or allergies to these medicines.
Riyadh, Riyadh RegionAges 18–70 - NCT06800846Enrolling by invitationPhase 4
Pain relief after knee replacement: injection methods compared
This study compares two ways to give pain medicine during knee replacement surgery: one is injected into the bone, the other around the joint. Researchers want to see which works better and may help you recover with less pain.
Khlong Luang, Changwat Pathum ThaniAges 50–80 - NCT07123805Recruiting
Acupuncture for knee replacement recovery
This study tests if adding acupuncture before and after knee replacement surgery helps reduce pain and improve recovery. It may be an option for people having planned knee replacement for osteoarthritis.
Pavia, PaviaAges 18 years+ - NCT07611526Recruiting
How Your Body Responds to Special Exercise After Knee Surgery
This study looks at how tired your leg muscles get during a new type of exercise training (called blood flow restriction training) after knee replacement surgery. The goal is to understand how this training affects your recovery and strength.
Bonn, North Rhine-WestphaliaAges 18–85
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Common questions
- Are there clinical trials for total knee anthroplasty?
- Yes. Clin2 currently lists 13 recruiting total knee anthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee anthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee anthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.