Clin2
NCT06801886Possibly a fitEnrolling by invitation

Silymarin for better kidney transplant success

Posttransplant Diabetes MellitusAcute Graft RejectionBiopsy Proven Acute RejectionAntibody Mediated Rejection of Kidney TransplantArterial Hypertension, Chronic Kidney Disease

Part of Heart & circulation, Kidney & urinary, Women’s health & pregnancy clinical trials.

This trial tests if adding silymarin (a milk thistle extract) to standard anti-rejection medicines helps protect the new kidney from damage. It may improve how well the transplanted kidney works over time.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
130 people
Ages
Any age
Study type
Interventional

Who can take part

  • You are getting your first or second kidney transplant from a living or deceased donor.
  • You are on standard anti-rejection medicines: tacrolimus or cyclosporine plus mycophenolate mofetil and steroids.
  • Your BMI is between 18 and 35.
  • You do not have active infections like HIV, hepatitis B or C, or CMV at the time of transplant.
  • You do not have serious liver disease, recent heart attack, or uncontrolled diabetes.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07508787Recruiting· Phase 2
Study comparing siplizumab to another drug for kidney transplant acceptance

This trial tests a new drug, siplizumab, to see if it helps the body accept a donated kidney better than a standard treatment. It is for people receiving a kidney transplant from a living or deceased donor.

Sacramento, California
NCT06751602Enrolling by invitation· Phase 2
Belumosudil to prevent kidney scarring after transplant

This trial tests whether a drug called belumosudil can reduce scarring in the kidney after transplant. Scarring can lead to kidney damage over time, and this study aims to stop that from happening.

Houston, Texas
NCT06990711Recruiting· Phase 1
Siltuximab for antibody-mediated rejection after lung transplant

This trial tests a drug called siltuximab to see if it can help treat a type of lung rejection called antibody-mediated rejection (AMR) in people who have had a lung transplant. You may be eligible if you are currently hospitalized for AMR and are already planning to receive standard treatments.

St Louis, Missouri
NCT06802822Not yet recruiting
Continuing anti-rejection medicine after a failed kidney transplant

This study tests whether continuing certain anti-rejection medicines while on dialysis can help lower the risk of your immune system becoming too sensitive to a future kidney transplant. It might help you stay eligible for another transplant later.

Vancouver, British Columbia
NCT07718633Not yet recruiting
Blood test for kidney transplant rejection

This trial tests a blood test that may help monitor kidney transplant health by detecting signs of rejection earlier. It aims to see if using this blood test can lead to better long-term outcomes for transplant recipients.

NCT07204080Not yet recruiting· Phase 2
New medicine to help prevent kidney transplant rejection

This study tests a new medicine called TNX-1500 that may help prevent the body from rejecting a new kidney. It is for people who are already waiting for a kidney transplant and aims to make the transplant more successful.

Boston, Massachusetts

Hear when a new Posttransplant Diabetes Mellitus trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.