Trial to reduce HIV reservoirs aiming for treatment-free remission
Treatments studied
Part of Immune system & allergy, Infections clinical trials.
This study tests whether a combination approach, including a drug called nicotinamide (a form of vitamin B3) and other strategies, can reduce the hidden HIV reservoir enough to allow a temporary pause in antiretroviral therapy without the virus rebounding. It is for people who have well-controlled HIV and strong immune systems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Aged 18 to 64 with documented HIV-1 infection.
- On the same HIV medications for at least 2 years, with no changes in the past 6 months.
- Undetectable HIV viral load (below 50 copies/mL) for the past 2 years without any blips.
- Lowest ever CD4 count above 350 and current CD4 count above 500.
- HIV virus type is R5 (as determined by a blood test).
- No active serious infections or other conditions that could interfere with the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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