Rebuilding neck lymphatics during head and neck cancer surgery
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new surgical technique to rebuild the lymphatic system in the neck during surgery for head and neck squamous cell carcinoma. It aims to reduce swelling and improve recovery after cancer removal.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stage T2, T3, or T4a head and neck cancer (with or without lymph node spread, but no spread to distant organs).
- You are between 18 and 75 years old.
- Your cancer has not spread to the lymph nodes under your arm (axilla).
- You have not had another type of cancer in the past.
- Your blood counts, liver, kidney, and heart function are within safe ranges (your doctor will check).
- You are not pregnant or breastfeeding, and you agree to use effective birth control during and after the study if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 2 study tests whether giving low-dose radiation before surgery—along with chemotherapy and an immunotherapy drug—can work better and be safe for treating locally advanced head and neck squamous cell cancer. It may help shrink tumors before surgery and reduce the chance of the cancer coming back.
This trial looks at whether giving less (de-escalated) radiation after surgery is as effective and safer for people with locally advanced head and neck squamous cell carcinoma who had a strong response to treatment before surgery. If you had no remaining cancer or only very small amounts of cancer left in the surgical specimen, this approach may help reduce side effects while keeping control of the disease.
This trial tests whether giving tislelizumab (an immunotherapy) with chemotherapy before surgery works better than surgery alone for people with head and neck cancer that has not spread to lymph nodes. It's for cancers that can be removed with surgery, and the goal is to see if the pre-surgery treatment improves outcomes.
This trial studies whether using a “fat flap” (a piece of your own fatty tissue, moved to the neck) during certain neck surgeries can reduce neck injury after head and neck cancer treatment. It is for people who need a salvage neck dissection because of persistent or returning cancer in the neck lymph nodes.
This study tests a surgical technique to rebuild neck veins during lymph node removal. It aims to prevent lymphedema (swelling) in head and neck cancer patients who need radiation after surgery.
This trial studies a specialized lymph surgery (called VLNT, moving lymph tissue) to treat swelling in an arm caused by breast cancer treatment. It may help reduce lymphedema that doesn’t fully improve with compression and elevation.
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