Topotecan eye injection to prevent repeat retinal detachment after surgery
Part of Eyes & vision clinical trials.
This study tests whether an injection of a drug called topotecan, given during or right after eye surgery for retinal detachment, can help prevent or treat a condition called proliferative vitreoretinopathy (PVR) that can cause the retina to detach again. If you're having surgery for a retinal detachment, this trial might help reduce the risk of needing more surgeries.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years old or older.
- You have a retinal detachment that needs surgery (like vitrectomy, scleral buckle, or pneumatic retinopexy).
- You are willing to receive an injection of the study drug into your eye.
- You are not planning to have other eye surgery after this one (unless it's part of the study).
- If you are a woman under 50, you must agree not to become pregnant during the study.
- You do not have severe diabetic eye disease, a history of a certain type of retinal detachment (exudative), or other health conditions like bone marrow problems or lung disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an experimental drug called topotecan, given as an injection directly into the eye during surgery, to see if it safely helps prevent scar tissue from pulling the retina out of place again. It is for people having surgery for retinal detachment with severe scarring or injury.
This study looks at imaging and blood-based markers to better understand retinal detachment. It aims to find ways to predict how well the retina might reattach after surgery.
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This Phase 2 trial tests an injection of topotecan into the eye after surgery for retinal detachment that keeps coming back due to scar tissue (proliferative vitreoretinopathy). It may help improve how the retina heals after difficult, repeat operations when vision is usually very guarded.
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