Catheter lock solution to prevent bloodstream infections in patients on IV nutrition
Treatments studied
Part of Infections clinical trials.
This study tests a catheter lock solution called DefenCath (taurolidine and heparin) against a standard heparin lock to see if it reduces central line bloodstream infections in people receiving IV nutrition (total parenteral nutrition) for more than 3 months.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 12 years old.
- You have a central venous catheter or PICC that is silicone or polyurethane and has been in place for at least 7 days.
- You need IV nutrition (TPN) for more than 3 months, at least 3 days per week, for at least 4 hours each day.
- You or a caregiver can be trained to use the catheter lock solution and keep a daily diary.
- You are not currently taking antibiotics by mouth or IV, except for certain specific ones.
- If you are of childbearing age, you agree to use birth control and have a negative pregnancy test before starting.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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