Long-term safety of plozasiran for high triglycerides
Part of Hormones & metabolism clinical trials.
This long-term study tests the safety and effectiveness of plozasiran for people with very high triglycerides. It's for those who already completed a previous plozasiran study and want to continue treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have completed all study visits in a previous Arrowhead study for plozasiran.
- You should be on standard cholesterol and triglyceride-lowering medications, unless you can't take them.
- If you have heart disease or a high risk for it, you need to be on appropriate treatment like a statin.
- If you have diabetes, it must be well controlled with no recent serious issues.
- You must be willing to limit alcohol to moderate levels and follow a low-fat diet.
- You cannot have had pancreatitis within the last 4 weeks.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new medication, SHR-1918, to lower high triglyceride levels. It may be an option for people with moderately elevated triglycerides and controlled cholesterol.
This study tests an investigational drug called plozasiran for people with severely high triglycerides that have already caused pancreatitis (inflammation of the pancreas). The goal is to see if the drug can lower triglycerides and help prevent future attacks.
This study is for people with psoriatic arthritis who have already completed a year-long treatment with zasocitinib or a similar medicine in a previous study. It tests whether continuing to take zasocitinib remains safe and helpful over a longer time.
This trial tests a new drug called AZD4954 for safety. It includes healthy volunteers and people with high Lp(a) or dyslipidemia. The goal is to see if the drug is safe and how the body processes it.
This Phase 2 trial studies how well and how safely orlistat works over the long term for people who have very high triglycerides linked to rare genetic lipid disorders. It may help lower triglycerides and assess long-term side effects, but you must meet specific genetic, lab, and health requirements.
This trial tests a new medicine called ISH0688 for safety and how the body processes it. It has two parts: one in healthy volunteers and one in people with high triglycerides, to see if the drug can help lower fats in the blood.
Hear when a new Hypertriglyceridemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.