Clot-busting therapy for stroke with active cancer
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests whether a clot-busting medicine (thrombolysis) can safely treat acute ischemic stroke in people who also have active cancer. It aims to see if the benefits of the treatment outweigh the bleeding risks for this group.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with active cancer (diagnosed, relapsed, or treated within the last 6 months).
- Your stroke symptoms started within the last 24 hours (or you woke up with symptoms that began within the last 24 hours from the middle of your sleep).
- You are 18 years old or older.
- You do not have any bleeding problems, such as recent major surgery, stomach or bladder bleeding, or a bleeding disorder.
- You are not taking certain blood thinners (like warfarin or apixaban) that would increase the risk of bleeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if a clot-dissolving medicine can help people who had a mild ischemic stroke and also had a prior stroke in the last 3 months. It aims to see if the treatment is safe and effective for this specific group.
This trial tests whether a clot-busting medication given through a vein (intravenous thrombolysis) can safely treat acute ischemic stroke within 24 hours in people who have taken a newer oral blood thinner (NOAC) within the last 4 to 48 hours.
This trial tests if a medication called tirofiban can help people who had a stroke 4.5 to 24 hours ago and received clot-dissolving treatment (IVT). If you have had a stroke and your symptoms did not improve or got worse after IVT, this study might offer a way to prevent further disability.
This trial tests whether giving a clot-dissolving medication directly into the brain's blood vessels during a standard procedure (mechanical thrombectomy) can improve outcomes for people with a stroke caused by a blockage in a medium-sized artery. It may be an option for patients who arrive at the hospital within 24 hours of symptom onset and have enough salvageable brain tissue.
This trial tests whether giving a clot-busting medication (tenecteplase) intravenously before mechanical thrombectomy—a procedure to physically remove a large blood clot from the brain—improves recovery better than thrombectomy alone in patients with large ischemic strokes.
This trial tests whether giving an antiplatelet medicine (like aspirin) early—within 3 hours of a clot-busting drug—can help prevent another stroke without causing bleeding. It is for people who still have moderate to severe stroke symptoms after the clot-buster and do not have a large artery blockage.
Hear when a new Stroke trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.