Clot-busting drug plus clot removal for large strokes
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether giving a clot-busting medication (tenecteplase) before the standard clot-removal procedure (thrombectomy) helps patients with a large stroke more than just the procedure alone. If the treatment works, it could improve recovery and reduce disability after a severe stroke.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Before this stroke, you were fully independent (able to live without help).
- Your stroke is caused by a blockage in a large artery in the front of your brain, and you can have a procedure (thrombectomy) to remove the clot within 24 hours of when symptoms started.
- You have a large area of brain damage (called a 'large core') – this will be confirmed by imaging (like an MRI or CT scan) once you are in the hospital.
- You must sign a consent form agreeing to participate, unless it's an emergency and you can't – then a family member or a trusted person can sign, or the doctor can include you if allowed by the hospital.
- You must not be pregnant or breastfeeding, and you must not have any medical reason that would make clot-busting medicine unsafe (like low blood platelets, recent surgery, or certain blood thinners).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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