Clot-Busting Drug Plus Mechanical Removal for Large Strokes
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether giving a clot-busting medication (tenecteplase) intravenously before mechanical thrombectomy—a procedure to physically remove a large blood clot from the brain—improves recovery better than thrombectomy alone in patients with large ischemic strokes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had a large stroke in the front part of your brain caused by a blood clot that can be surgically removed
- Symptoms started within 24 hours, or time is unknown but imaging shows signs of recent stroke
- You were independent and able to care for yourself before the stroke (minimal disability)
- You have no serious bleeding disorders, recent major surgery, or other medical conditions that would make clot-busting medication unsafe
- You can have imaging (CT or MRI) to confirm the size and location of the clot
- You are not pregnant and have a French social security number
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether giving a clot-busting drug called tenecteplase directly into the brain's blood vessels can help complete the removal of a clot after a first attempt at mechanical extraction was only partially successful.
This trial tests a procedure to remove a large blood clot in the brain (mechanical thrombectomy) for people who have a very large stroke. It aims to see if removing the clot can improve recovery, even for those with severe strokes.
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