Efgartigimod for worsening myasthenia gravis in hospital
Treatments studied
Part of Brain & nervous system, Immune system & allergy clinical trials.
This trial tests a drug called efgartigimod for people with myasthenia gravis who are in the hospital because their symptoms are getting worse. The goal is to see if it can help them recover faster and avoid needing a breathing tube.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You have generalized myasthenia gravis with a positive blood test for acetylcholine receptor antibodies.
- Your MG symptoms are severe enough to need a hospital stay, such as trouble breathing, swallowing, or speaking.
- You are able to join the study within 24 hours of being admitted to the hospital.
- You have not had certain other treatments recently, like IVIG (intravenous immunoglobulin) in the last 2 weeks, or plasma exchange or efgartigimod in the last 4 weeks.
- You are not currently pregnant or breastfeeding, and you are not on certain other MG medications like ravulizumab or eculizumab.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a drug called efgartigimod (given through an IV) to see if it can help people who are in a myasthenic crisis — a severe flare-up of myasthenia gravis that makes it hard to breathe. The goal is to help patients recover faster from this dangerous worsening of symptoms.
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