Comparing two add-on treatments for type 2 diabetes
Part of Hormones & metabolism clinical trials.
This trial compares adding a new pill (cofrogliptin) to increasing your current metformin dose, for people whose blood sugar is still too high despite taking an SGLT2 inhibitor and a low dose of metformin. The goal is to see which option works better and is safer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age between 18 and 74 years old
- Diagnosed with type 2 diabetes
- Currently taking a standard SGLT2 inhibitor pill for at least 8 weeks
- Taking 500–1000 mg of metformin daily for at least 8 weeks, with no recent dose changes
- Your HbA1c (average blood sugar over 2-3 months) is between 7.5% and 9.5%
- Your fasting blood sugar is below 15 mmol/L
- Weigh less than 40 on the BMI scale
- No ketones in your urine (a sign of serious diabetes complication)
- Kidney function (eGFR) is 60 or higher
- Able to monitor your blood sugar at home and stick with your current diet and exercise plan
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding either cofrogliptin or linagliptin (two pills that help control blood sugar) to your current insulin treatment can improve diabetes control. It is for adults with type 2 diabetes whose blood sugar is still not well managed with insulin and certain other diabetes pills.
This trial tests a new pill called cofrogliptin against a standard medicine called acarbose to see which better controls blood sugar in people with type 2 diabetes who have never taken diabetes medication. It's for those managing their diabetes with diet and exercise alone.
This trial compares two medications, dapagliflozin and empagliflozin, to see which works better and is safer for people with type 2 diabetes and a high body mass index (BMI). If you are an adult with type 2 diabetes and a BMI of 23 or higher, this study might help find a treatment that also supports weight loss.
This trial tests how combining a ketone supplement with certain diabetes medicines affects blood sugar and ketone levels. It may help adults with type 2 diabetes who are not on insulin or certain other drugs.
This trial tests a combination of three common diabetes medications (metformin, an SGLT2 inhibitor, and a TZD) to see how well they work together and if they are safe. It may help people with type 2 diabetes who need better blood sugar control.
This trial is testing a combination of three diabetes medicines (henagliflozin, retagliptin, and metformin) in people newly diagnosed with type 2 diabetes. The goal is to see if this triple therapy works better for controlling blood sugar compared to standard treatments.
Hear when a new Type 2 diabetes trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.