Study of diabetes drugs and ketones
Treatments studied
Part of Hormones & metabolism clinical trials.
This trial tests how combining a ketone supplement with certain diabetes medicines affects blood sugar and ketone levels. It may help adults with type 2 diabetes who are not on insulin or certain other drugs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 30 and 75 years old.
- Your body mass index (BMI) is between 21 and 45.
- Your HbA1c (average blood sugar over 3 months) is between 7.0% and 11%.
- Your kidney function is good (eGFR above 60).
- Your blood pressure is 160/90 or lower.
- You have been on a stable dose of metformin, a sulfonylurea, or both for at least 3 months (or a GLP-1 drug for 3 months, or a DPP-4 inhibitor for 2 months).
- You have not taken a SGLT2 inhibitor (like canagliflozin) in the last 2 months, and you have not taken TZDs or insulin.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests how stopping a type 2 diabetes medication called an SGLT2 inhibitor affects the liver's production of sugar and ketones. It may help understand better ways to manage diabetes.
This study looks at how stopping a common diabetes drug (SGLT2 inhibitor) affects the body's risk of a serious condition called ketoacidosis. It may help understand who is most at risk and how to prevent it.
This study tests how a type of diabetes medicine called SGLT2 inhibitors affects how the liver makes sugar. It may help researchers better understand how to manage blood sugar in people with type 2 diabetes.
This study tests different ways to monitor ketones (substances that can build up dangerously when your body lacks insulin) to lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT-2 inhibitors (a type of diabetes drug). You'll wear a small sensor and follow a meal plan with carbs.
This trial compares adding a new pill (cofrogliptin) to increasing your current metformin dose, for people whose blood sugar is still too high despite taking an SGLT2 inhibitor and a low dose of metformin. The goal is to see which option works better and is safer.
This trial tests how two diabetes medications, SGLT2i and pioglitazone, affect ketone production in people with type 1 diabetes. It aims to find new ways to improve blood sugar control.
Hear when a new Type 2 diabetes trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.