Minimally invasive clot removal with tenecteplase for deep brain bleed
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests a minimally invasive procedure to remove deep brain bleeds using a special puncture guided by brain imaging, combined with a clot-dissolving drug called tenecteplase. It may help reduce damage from the bleed and improve recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 79 years old.
- You had a spontaneous deep brain bleed (in the basal ganglia or thalamus) that is 20 to 50 mL in size.
- Your symptoms started within 24 hours of your first CT scan.
- A follow-up CT scan at least 6 hours later shows the bleed has stopped growing (less than 5 mL increase).
- You have a Glasgow Coma Scale score between 5 and 14 (meaning you are not fully awake but respond to some stimulation).
- You are not taking blood thinners (like warfarin, apixaban, or clopidogrel) and do not have a bleeding disorder.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new way to remove brain blood clots using a small tube and a clot-busting medicine (tenecteplase). It aims to help people recover better after a specific type of bleeding in the brain.
This trial tests a less invasive surgery to remove small blood clots (20–30 ml) in the basal ganglia, a deep part of the brain. It may help people who are awake but have a reduced level of consciousness after a recent brain bleed.
This trial tests a clot-busting drug (rhTNK-tPA) to remove blood from the ventricles (fluid spaces deep in the brain) after a spontaneous brain bleed. It may help patients whose ventricles are blocked by a large clot, reducing pressure and improving recovery.
This trial tests a minimally invasive surgery to remove blood clots deep in the brain after a spontaneous bleed. It may help patients with moderate to large bleeds who are at least 18 and up to 80 years old.
This trial tests a clot-busting drug called tenecteplase given directly into the brain bleed through a thin tube. It may help reduce damage and improve recovery for people with a certain type of brain hemorrhage.
This trial studies whether a special scan-guided, minimally invasive procedure can safely remove bleeding in the basal ganglia (deep in the brain) soon after it happens. It may help patients recover better by targeting the bleeding while protecting important brain pathways.
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