Retina immune cell study for dry AMD, MCI, or mild Alzheimer's
Part of Brain & nervous system, Mental health clinical trials.
This study uses a special dye and imaging to see if certain immune cells (dendritic cells) travel to the retina. It aims to understand how the immune system might play a role in dry age-related macular degeneration, mild cognitive impairment due to Alzheimer's, or early Alzheimer's disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 55 to 80 years old.
- In generally good health, with stable medications for at least one month.
- For healthy volunteers: normal memory and thinking tests, no family history of Alzheimer's, no evidence of eye disease (other than needing glasses) or neurologic disease.
- For dry AMD: advanced dry AMD with specific types of damage in the retina, vision better than 20/80, and not currently using injectable medications for AMD.
- For MCI or mild Alzheimer's: mild memory or thinking problems, a positive Alzheimer's biomarker (like a blood test), and a study partner (family/friend) to attend visits.
- No autoimmune diseases (like rheumatoid arthritis or lupus), no unstable heart or lung conditions, no recent drug or alcohol problems, and no use of certain immune-suppressing or antipsychotic medications.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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