Medication with or without a special diet for weight regain after bariatric surgery
Part of Hormones & metabolism clinical trials.
This study tests if a combination of two drugs (naltrexone and bupropion) with or without a very low-calorie ketogenic diet can help people who have regained weight after gastric bypass or sleeve gastrectomy. It may offer a non-surgical option to manage weight regain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had either a gastric bypass (RYGB) or sleeve gastrectomy (SG) for weight loss.
- You regained at least 10% of your lowest weight after surgery.
- You do not have type 2 diabetes (no diabetes history, no diabetes drugs, and recent blood sugar tests are below certain levels).
- You are not currently taking any other weight-loss drugs (like GLP-1 receptor agonists) or have stopped them at least 3 months ago.
- If you are a woman who can become pregnant, you agree to use highly effective birth control during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests how a special diet after weight-loss surgery affects gut bacteria, eating habits, and sense of taste and smell. Researchers want to see if this diet can improve long-term results.
This study looks at whether a specific stomach bypass revision (a “distal gastric bypass”) can improve outcomes after Roux-en-Y gastric bypass when weight loss was not enough or weight was regained. You may be considered if you meet weight-loss goals criteria and can join follow-up and possibly surgery.
This study looks at whether adding medication to lifestyle counseling can help people who have regained weight after sleeve gastrectomy or gastric bypass. It focuses on improving weight control and related health after surgery.
This study tests whether adding a medication (naltrexone/bupropion) to sleeve gastrectomy surgery can improve weight loss. It may be a good fit if you are eligible for a first-time sleeve gastrectomy and meet certain health criteria.
This study tests if the medication Remi can help people who have gained back at least 5% of their lowest weight after gastric bypass or sleeve gastrectomy. It is meant for those who are not currently using other weight loss drugs and are otherwise healthy enough to participate.
This trial studies how your genetic makeup and body response may affect weight loss with a medication combination called naltrexone and bupropion. If you qualify, you’ll likely take these medicines and be monitored for safety and changes in weight over time.
Hear when a new Obesity (Disorder) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.