Testing TNP-2092 for knee infection after joint replacement
Treatments studied
Part of Bones, joints & muscles, Infections clinical trials.
This trial tests a new antibiotic, TNP-2092, given as a shot directly into the knee joint for people with a persistent infection after knee replacement. It is for those whose infection is caused by certain bacteria and who are willing to stay in the hospital for 2 weeks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a knee replacement that became infected within the first month after surgery, or suddenly within 3 weeks of infection symptoms.
- The infection is suspected or confirmed to be caused by a type of bacteria called Gram-positive (like staph), including hard-to-treat strains.
- You are willing to stay in the hospital for 2 weeks to receive the antibiotic shots into your knee joint.
- You are 18 years or older.
- Your knee implant is well-fixed and you do not have a sinus tract (a tunnel) leading from the implant to the skin.
- Your body mass index (BMI) is between 18 and 34.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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