A pain pill that may reduce constipation for severe cancer pain
Part of Mental health, Pain clinical trials.
This study tests a combination pill (oxycodone with naloxone) that may treat severe cancer pain while also helping with constipation — a common side effect of opioid pain medicines. It is designed for people whose constipation is linked to their painkillers.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years of age or older.
- Have advanced cancer confirmed by a biopsy or other tests.
- Have severe cancer pain (a score of 7 or higher on a 0-10 scale) and be currently using opioid pain medicines.
- Have constipation that started or worsened after you began taking opioids (a common side effect).
- Be expected to live for more than 3 months.
- Be willing to sign a consent form to take part.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how well naldemedine (and certain other constipation medicines) lower the risk of major heart problems in people who take opioids for constipation. It compares medicine use patterns in people with opioid-induced constipation to see who has fewer serious heart events.
This trial tests a new treatment for constipation caused by opioid pain medication. It aims to see if it's safe and effective, and may help you have more regular bowel movements.
This trial tests whether starting a laxative right away can prevent constipation caused by pain medications called opioids. It's for people with advanced cancer who are beginning opioid pain treatment and aims to improve comfort and quality of life.
This study tests how well and how safely OxyContin, a pain medicine, works when started at home (outpatient) for people with moderate to severe cancer pain. It aims to help patients manage pain more easily while staying at home.
This trial tests whether naldemedine, a medication for constipation, can help cancer patients who have constipation caused by opioids. It looks at how well it works and how patients feel.
This study tests whether a new pain medication called 3D1002, when combined with a long-acting opioid, can better manage moderate to severe cancer pain compared to the opioid alone. The goal is to find a more effective way to reduce pain without increasing side effects.
Hear when a new Opioid-Induced Constipation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.