Testing medicines to prevent heart events in opioid constipation
Part of Mental health clinical trials.
This study looks at how well naldemedine (and certain other constipation medicines) lower the risk of major heart problems in people who take opioids for constipation. It compares medicine use patterns in people with opioid-induced constipation to see who has fewer serious heart events.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have been getting prescriptions for opioids at least two times in the last 6 months, totaling at least 31 days of supply.
- You have health insurance coverage with both medical and pharmacy benefits continuously for at least 6 months before starting the study medicines.
- You have not used naldemedine, lubiprostone, or naloxegol before the start date.
- You did not have a heart attack or stroke in the 6 months before the start date.
- You have not had cancer treatment or cancer-related pain in the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a combination pill (oxycodone with naloxone) that may treat severe cancer pain while also helping with constipation — a common side effect of opioid pain medicines. It is designed for people whose constipation is linked to their painkillers.
This Phase 2 study looks at what opioid withdrawal looks like in the body and whether they can measure it in a meaningful way. You may join if you have an opioid use disorder, can show physical dependence, and are interested in tapering (gradually reducing) opioids under study care.
This study tests whether naldemedine is safe and how the body processes it in children who take opioid medicines and are dealing with constipation or are at risk for it. It may help some children by reducing constipation side effects from opioid pain treatment.
This trial tests whether naldemedine, a medication for constipation, can help cancer patients who have constipation caused by opioids. It looks at how well it works and how patients feel.
This trial tests whether starting a laxative right away can prevent constipation caused by pain medications called opioids. It's for people with advanced cancer who are beginning opioid pain treatment and aims to improve comfort and quality of life.
This trial tests a new treatment for constipation caused by opioid pain medication. It aims to see if it's safe and effective, and may help you have more regular bowel movements.
Hear when a new Opioid-induced Constipation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.