Clin2
NCT06910072Possibly a fitEnrolling by invitation

Chemo and immunotherapy before surgery for triple-negative breast cancer

Triple-Negative Breast Cancer (TNBC)Neoadjuvant Therapy

Part of Cancer, Skin clinical trials.

This trial tests a combination of chemotherapy and two immunotherapy drugs given before surgery for women and men with triple-negative breast cancer. The goal is to see if this approach helps shrink or eliminate the tumor before surgery.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
32 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You must have triple-negative breast cancer
  • The main tumor must be at least 2 cm in size and cancer stage 2 or 3
  • You must be able to do daily activities without help (ECOG score 0 or 1)
  • Women who can become pregnant need a negative pregnancy test and must use effective birth control during treatment and for 6 months after
  • You cannot have had breast cancer before or any other cancer in the last 5 years (except some easily treated skin cancers)
  • You cannot have an autoimmune disease (like lupus) that needs treatment, or a weak immune system

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07786428Not yet recruiting· Phase 2
Chemoimmunotherapy before surgery for early triple negative breast cancer

This study tests giving a combination of chemotherapy and immunotherapy before surgery for early stage triple negative breast cancer. The goal is to see if this approach can improve treatment outcomes and reduce the chance of the cancer coming back.

Dallas, Texas
NCT07187674Not yet recruiting
Combination treatment before surgery for early high-risk triple negative breast cancer

This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) with a PARP inhibitor (olaparib) and a chemotherapy drug (paclitaxel) before surgery for early high-risk triple negative breast cancer that is HRD positive. It aims to shrink or eliminate the tumor to improve long-term outcomes.

NCT07342283Recruiting· Phase 2
QL1706 plus chemo before surgery for triple-negative breast cancer

This trial tests a combination of an immunotherapy drug (QL1706) plus standard chemotherapy given before surgery to shrink triple-negative breast cancer. The goal is to see if this approach helps remove the tumor more completely.

Nantong, Jiangsu
NCT06845319Recruiting· Phase 2
Chemo-immunotherapy before surgery for triple-negative breast cancer

This trial tests a new combination of chemotherapy and immunotherapy that avoids a class of drugs called anthracyclines, which can be hard on the heart. The goal is to shrink tumors before surgery for people with triple-negative or low-hormone-receptor breast cancer.

Charleston, South Carolina
NCT06817525Recruiting· Phase 2
Chemo and immunotherapy before surgery for early triple-negative breast cancer

This trial tests whether a combination of chemotherapy drugs (nab-paclitaxel and carboplatin) plus an immunotherapy drug (PD1 inhibitor) given before surgery can help treat early-stage triple-negative breast cancer. It aims to improve outcomes by using these treatments before the main surgery.

Zhengzhou, Henan
NCT06407310Not yet recruiting· Phase 2
Immunotherapy and chemotherapy before surgery for early triple-negative breast cancer

This trial tests whether giving pembrolizumab (an immunotherapy drug) together with chemotherapy before surgery can help treat early-stage triple-negative breast cancer. It aims to improve outcomes by shrinking the tumor before removal.

Hear when a new Neoadjuvant Therapy trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.