Clinical trials
Neoadjuvant Therapy clinical trials
Below are recruiting neoadjuvant therapy clinical trials, each written for real people, not researchers. We’re tracking 359 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06766578RecruitingPhase 2
Low-dose radiation plus immunotherapy and chemo before gastric cancer surgery
This trial tests a new combination of low-dose radiation, an immunotherapy drug (tirelizumab), and chemotherapy (SOX) given before surgery for locally advanced gastric or gastroesophageal junction cancer. The goal is to see if this approach can shrink tumors more effectively.
Jinan, ShandongAges 18–75 - NCT06052332Recruiting
Comparing two pre-surgery treatments for older adults with rectal cancer
This study compares two approaches to treating rectal cancer in people age 70 and older who have not yet had surgery. One approach gives chemotherapy and radiation before surgery, and the other adds more chemotherapy after radiation. The goal is to find which plan works better with fewer side effects.
Antwerp, AntwerpenAges 70 years+ - NCT06642428Recruiting
Vitamin D for breast cancer treatment before surgery
This trial tests whether taking vitamin D pills during chemotherapy or targeted therapy (before breast cancer surgery) can improve how well the treatment works and reduce side effects. It is for women with low vitamin D levels.
Xining, QinghaiAges 18–80 - NCT06913777RecruitingPhase 3
Precision therapy before surgery for HR-positive breast cancer
This trial tests a new precision therapy given before surgery for women with a specific type of HR-positive breast cancer. It aims to see if this treatment can improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06990178Enrolling by invitation
Adaptive Neoadjuvant Therapy for Esophageal Cancer
This trial is testing a new treatment approach for esophageal cancer that includes chemotherapy and immunotherapy before surgery. The goal is to see if this combination can help shrink the tumor and improve outcomes.
Shenzhen, GuangdongAges 18–75 - NCT05378919RecruitingPhase 2
Testing new pre-surgery treatment for locally advanced rectal cancer
This Phase 2 trial compares a pre-surgery (neoadjuvant) treatment plan versus the standard plan for people with stage II–III rectal cancer. The goal is to see which approach works better and is safe before surgery.
KaunasAges 18 years+ - NCT06829797RecruitingPhase 2
Iparomlimab and chemotherapy vs chemotherapy alone for stomach cancer
This trial tests whether adding an immunotherapy drug (Iparomlimab and Tuvonralimab, combined as QL1706) to standard chemotherapy before surgery works better than chemotherapy alone for people with locally advanced stomach or gastroesophageal junction cancer that can be surgically removed.
Jinan, ShandongAges 18–75 - NCT07541664Recruiting
Digital Mind-Body Therapy for Breast Cancer Patients
This study tests a smartphone app that combines relaxation techniques and mental health support for women receiving chemotherapy before breast cancer surgery. It aims to reduce anxiety, depression, sleep problems, and emotional distress during cancer treatment.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT03926338RecruitingPhase 2
Before-surgery immunotherapy for MSI-H or dMMR colon cancer
This trial studies a treatment given before surgery using toripalimab, with or without celecoxib, for colon or rectal cancer that has MSI-H or dMMR tumor features. It aims to shrink or control the cancer before the operation and compare whether adding celecoxib helps.
Guangzhou, GuangdongAges 18–75 - NCT07198165RecruitingPhase 2
Short radiation followed by chemo plus bevacizumab with or without immunotherapy for rectal cancer
This trial tests whether adding an immunotherapy drug (PD-1 inhibitor) to standard chemoradiation and targeted therapy improves outcomes for locally advanced rectal cancer. It is for patients who have not had prior treatment and do not have certain genetic markers (BRAF mutation or MSI-H).
ShanghaiAges 18–75 - NCT06002789RecruitingPhase 2
PD-1 immunotherapy with or without chemo before surgery for colorectal cancer
This trial tests a medicine called PD-1 (a type of immunotherapy that helps your immune system fight cancer), sometimes with chemotherapy, before surgery for a certain type of colorectal cancer. It is for people whose tumors have a specific DNA repair problem (dMMR or MSI-H) and whose cancer has not spread to distant organs.
Guangzhou, GuangdongAges 18–80 - NCT06758830RecruitingPhase 2/Phase 3
Total neoadjuvant therapy vs surgery for rectal cancer
This trial tests whether a full course of chemotherapy and radiation before any surgery (called total neoadjuvant therapy) can help you avoid surgery and preserve your rectum. It is for people with a specific early stage of rectal cancer that has not spread.
VilniusAges 18 years+ - NCT07135856Recruiting
Lung-saving surgery after pre-surgery therapy for NSCLC
This trial studies how well sleeve lobectomy (a type of lung-saving surgery) works for people with non-small cell lung cancer who have already received therapy like chemotherapy or immunotherapy before surgery. It aims to see if this approach is safe and effective.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT04743102Recruiting
Multi-point full-thickness biopsy to confirm complete rectal cancer response
This trial checks whether taking small samples from the full thickness of rectal tissue can accurately confirm that rectal cancer has fully responded to chemotherapy and/or radiation. It may help doctors decide the best next step if no tumor is seen after treatment.
Beijing, Beijing MunicipalityAges 18–80 - NCT07324824RecruitingPhase 2
Sintilimab plus bevacizumab before surgery for liver cancer
This trial tests two drugs, sintilimab and bevacizumab, given before surgery to treat liver cancer that can be removed. It's for people with a certain stage of liver cancer who haven't had other treatments.
Guangzhou, GuangdongAges 18 years+ - NCT07383818RecruitingPhase 2
Neoadjuvant therapy with trastuzumab rezetecan and toripalimab for HR+/HER2-low breast cancer
This trial tests a combination of two drugs (trastuzumab rezetecan and toripalimab) given before surgery to treat a specific type of breast cancer that is hormone-receptor-positive and HER2-low. It aims to see if this treatment can improve outcomes for patients who have not had prior cancer treatment.
HarbinAges 18–70 - NCT06014372RecruitingPhase 2
Envafolimab before surgery for advanced rectal cancer
This trial tests envalolimab (an immunotherapy) alone or with chemo (CAPEOX) before surgery for locally advanced rectal cancer. It aims to shrink the tumor and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06405321Recruiting
Initial therapy before surgery for liver cancer
This trial looks at how well certain initial treatments (like targeted therapy, immunotherapy, or liver-directed procedures) work in people with liver cancer who have not had surgery yet. It aims to see if these treatments can shrink the tumor enough to allow removal later.
Nanning, ChinaAges 18–75 - NCT07422974Recruiting
Surgery results after pre-treatment for colorectal cancer
This study looks at how well patients recover from colorectal cancer surgery, comparing those who had chemotherapy or radiation before surgery to those who did not. The goal is to understand if pre-treatment affects surgical outcomes.
OsijekAges 18 years+ - NCT04486495Recruiting
Minimally invasive lymph node treatment after chemo for node-positive breast cancer
This study looks at a less invasive way to check and treat lymph nodes in the armpit after you receive chemotherapy (and sometimes immunotherapy) before breast surgery. It may help people with cancer that has already spread to armpit lymph nodes by improving how staging and treatment are done.
's-HertogenboschAges 18 years+ - NCT07388771Recruiting
Predicting treatment results for lung cancer before surgery
This trial is testing a treatment given before surgery for non-small cell lung cancer. Patients receive chemotherapy plus immunotherapy (chemo-immunotherapy) first, then have surgery to remove the tumor. The goal is to see how well this approach works.
Wuhan, HubeiAges 18 years+ - NCT06802666RecruitingPhase 2
Short radiation plus combo drugs for rectal cancer
This trial tests a new combination for rectal cancer that hasn't spread far: a short course of radiation followed by two drugs (AK112 and CAPOX). The goal is to shrink the tumor before surgery and possibly avoid more aggressive treatments.
HubeiAges 18–75 - NCT07386158RecruitingPhase 2
Immunotherapy before surgery for clear cell kidney cancer
This trial tests whether giving pucotenlimab (an immunotherapy drug) with vorolanib (a targeted therapy) before surgery helps shrink clear cell kidney tumors and makes kidney-sparing surgery safer. It is for people with localized, non-metastatic disease where the tumor is difficult to remove with partial nephrectomy.
Guangzhou, Other (Non U.s.)Ages 18–85 - NCT06895447RecruitingPhase 2
Robot-assisted stomach cancer surgery after chemo or radiation
This trial tests whether using a robotic arm to remove stomach cancer is safe and effective for patients who have already received chemotherapy or radiation. If you have stage III stomach cancer and are healthy enough for surgery, this approach may offer a more precise operation.
Nanjing, JiangsuAges 18–80
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Common questions
- Are there clinical trials for neoadjuvant therapy?
- Yes. Clin2 currently lists 359 recruiting neoadjuvant therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neoadjuvant therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neoadjuvant therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.