Clin2
NCT06910241Possibly a fitRecruiting

Lidocaine vs. Diphenhydramine for Stitches in ER

Laceration of Skin

Treatments studied

Part of Injuries & trauma, Skin clinical trials.

This trial compares two numbing medicines—lidocaine and diphenhydramine—to see which works better for stitching up cuts in the emergency room. It helps find the fastest, most comfortable option for people needing stitches.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
100 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have a cut that can be fixed with one layer of stitches.
  • The cut is not bleeding heavily.
  • You are not allergic to lidocaine or diphenhydramine (Benadryl).
  • A specialist does not need to close your cut.
  • The doctor doesn't think epinephrine needs to be added to the numbing medicine.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05383495Recruiting· Phase 3
Calming medicine during child laceration repair

This trial tests a calming/anxiety-reducing medicine to see if it helps children feel less scared during stitches for a skin cut. It may help make the repair process easier for children and their caregivers.

London, Ontario
NCT05934669Recruiting· Phase 4
Numbing medicines compared for small stitches in young children

This trial tests three medicines given through the nose to keep children comfortable during minor procedures in the emergency department, specifically for closing small cuts with stitches. It may help find which nasal medicine works best and is safest for quick, minimal procedures.

Oklahoma City, Oklahoma
NCT07872891Not yet recruiting
Hypnosis for pain during emergency stitches

This trial tests whether using hypnosis during stitches in the emergency room can reduce pain. If you need a single stitch for a wound, this approach might help you feel less discomfort.

NCT07034300Recruiting· Phase 4
Comparing lidocaine with and without dexmedetomidine for arm surgery

This trial tests whether adding dexmedetomidine to lidocaine works better for numbing the arm during surgery. Patients get numbing medicine through a special IV in the arm while the surgery is happening.

Lahore, Punjab Province
NCT07224711Not yet recruiting· Phase 4
Lidocaine infusion for faster recovery after non-cardiac surgery

This study tests whether giving a lidocaine drip during and after major surgery helps patients recover faster and use less pain medicine. Lidocaine is a numbing medicine that may reduce pain and speed up recovery.

Nashville, Tennessee
NCT07675616Recruiting
Comparing two drugs for numbing the eye before tear-duct surgery

This trial tests whether adding dexmedetomidine or magnesium sulfate to lidocaine makes numbing the eye more effective for tear-duct surgery. The goal is to find which combination provides better pain control during surgery.

Cairo

Hear when a new Laceration of Skin trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.