Treatment
Diphenhydramine clinical trials
We’re tracking 16 recruiting studies that include Diphenhydramine, each written for real people, not researchers, below.
Recruiting studies
- NCT07542730RecruitingPhase 4
Diphenhydramine to ease discomfort during early abortion procedure
This study tests whether adding diphenhydramine (a common allergy medicine) to sedation helps patients feel more comfortable during a procedural abortion in the first trimester. Researchers want to see if it improves pain control and overall experience.
Rochester, New YorkAges 18 years+ - NCT06910241RecruitingPhase 3
Lidocaine vs. Diphenhydramine for Stitches in ER
This trial compares two numbing medicines—lidocaine and diphenhydramine—to see which works better for stitching up cuts in the emergency room. It helps find the fastest, most comfortable option for people needing stitches.
Boynton Beach, FloridaAges 18 years+ - NCT05501678RecruitingPhase 2
Diphenhydramine to help sleep in autistic children
This Phase 2 study tests whether diphenhydramine improves sleep in children with autism who have significant sleep problems. It requires sleep monitoring (watch data and sleep testing) and checking for side effects to see if the treatment is safe and helpful.
Stanford, CaliforniaAges 8–17 - NCT07542756RecruitingPhase 4
Testing Common Sleep Medications for Insomnia
This study compares how well different over-the-counter and prescription sleep medications work for insomnia. Researchers will guide you through trying medications one at a time to find what works best for your sleep problems.
Philadelphia, PennsylvaniaAges 18–80 - NCT07570173RecruitingPhase 2/Phase 3
MK-1045 for Hard-to-Treat B-Cell Leukemia
This trial tests a new drug called MK-1045 in patients whose acute lymphoblastic leukemia (a blood cancer) has come back or stopped responding to previous treatments. The goal is to see if this drug can help control the cancer when other options haven't worked.
Copenhagen, Capital RegionAges 12 years+ - NCT06070649RecruitingPhase 1
DMT for Alcohol Use Disorder
This trial tests whether a single dose of DMT, a psychedelic, can help people with alcohol use disorder. It's a small early-phase study to see if the treatment is safe and promising.
New Haven, ConnecticutAges 21–65 - NCT07285031Recruiting
Histamines and blood vessel health study
This study looks at how histamines affect blood pressure and heart function in healthy young adults. You will visit the lab three times to help researchers understand these effects.
Kelowna, British ColumbiaAges 19–39 - NCT06819774RecruitingPhase 3
Testing cetirizine injection for acute hives
This trial tests an injectable medication (cetirizine, a type of antihistamine) to see if it quickly relieves itching and hives in adults with acute (short-term) hives. It is for people whose hives have lasted less than 6 weeks and who still have bothersome symptoms.
Beijing, Beijing MunicipalityAges 18–65 - NCT06356571RecruitingPhase 2
Isatuximab with carfilzomib and dexamethasone for multiple myeloma
This trial tests a new combination of drugs (isatuximab, carfilzomib, and dexamethasone) given as shots under the skin for people whose multiple myeloma has come back or stopped responding to treatment. It aims to see if this mix works better than previous options.
Phoenix, ArizonaAges 18 years+ - NCT05039619RecruitingPhase 2
Obinutuzumab trial for adolescents with active lupus kidney inflammation
This Phase 2 study tests obinutuzumab, a targeted antibody medicine, in teens with active lupus nephritis (inflammation in the kidney). It looks at whether it helps kidney disease and is safe, including how the body handles the drug.
Loma Linda, CaliforniaAges 5–17 - NCT04224558RecruitingPhase 1/Phase 2
Stem cell transplant for hard-to-control Crohn’s disease
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
Los Angeles, CaliforniaAges 13–28 - NCT05896228RecruitingPhase 2
Combination therapy for relapsed multiple myeloma to target MRD
This Phase 2 trial tests iberdomide plus daratumumab, carfilzomib, and dexamethasone in people whose multiple myeloma has come back or not responded. The goal is to increase how often patients reach “MRD-negative” status, meaning very small amounts of cancer cells are not detectable, which may help improve outcomes.
Miami, FloridaAges 18–75 - NCT05977998RecruitingPhase 2
Paclitaxel given during surgery for stomach cancer spread to the belly
This trial studies whether adding paclitaxel chemotherapy around the time of surgery can improve outcomes for people with stomach or gastroesophageal junction adenocarcinoma that has spread to the lining of the abdomen (peritoneum). It targets cancers confirmed by testing of belly fluid or by laparoscopy/laparotomy, and may help by treating cancer cells right at the time of surgery.
Houston, TexasAges 18 years+ - NCT06043323RecruitingPhase 2
CAR T cells plus radiation for follicular lymphoma
This trial tests a combination of a CAR T-cell therapy (Axicabtagene Ciloleucel) with radiation therapy for people with follicular lymphoma that has come back or not responded to multiple treatments. The goal is to see if adding radiation can make the CAR T cells work better.
Houston, TexasAges 18 years+ - NCT06207305RecruitingPhase 1/Phase 2
Paclitaxel into the belly for appendix cancer
This trial tests a chemotherapy drug (paclitaxel) given directly into the belly for people whose appendix cancer has spread inside the belly and cannot be surgically removed. The goal is to see if this approach is safe and helps shrink tumors.
Houston, TexasAges 18 years+ - NCT06702670RecruitingPhase 2/Phase 3
Anticholinergics for cervical edema in labor
This trial tests if a medication (diphenhydramine) can help reduce swelling in the cervix during labor for first-time mothers. It may make labor progress more smoothly.
Houston, TexasAges 18 years+
What Diphenhydramine is being studied for
Conditions with recruiting Diphenhydramine studies.
Common questions
- Are there clinical trials studying Diphenhydramine?
- Yes. Clin2 currently lists 16 recruiting studies that include Diphenhydramine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Diphenhydramine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Diphenhydramine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Diphenhydramine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.