Esketamine plus nerve block for shingles-related pain
Part of Brain & nervous system, Pain clinical trials.
This study tests a combination of two treatments for long-term nerve pain after shingles: a medication called esketamine and a nerve block (pulsed radiofrequency) applied to the affected spinal nerves. The goal is to see if this combination relieves the burning or shooting pain better than the nerve block alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- You have had pain for more than 3 months after shingles (a skin rash caused by the chickenpox virus).
- The pain is on one side of your body, in the neck, chest, back, or lower back area.
- Your average pain score is at least 4 out of 10 (where 0 is no pain and 10 is the worst possible pain).
- You have not had radiofrequency thermocoagulation (a heat-based treatment to block nerves) for this pain.
- You do not have certain health conditions (like sleep apnea, severe heart/lung/liver/kidney problems, or immune diseases) and are not pregnant or planning to become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This trial tests whether adding esketamine to two standard pain medicines (pregabalin and duloxetine) can better treat nerve pain from shingles that persists for months. It's for people whose pain hasn't improved enough with pregabalin alone.
This study tests a treatment called peripheral nerve stimulation (using a small device to send mild electrical pulses) for people with nerve pain after shingles. It's designed for those whose pain is not well managed by usual treatments.
This trial tests if a nerve block with betamethasone can reduce long-term shingles pain on the trunk. It may help people who still have pain more than 3 months after the rash appeared.
This trial tests a pain-relieving brain stimulation treatment for people with long-lasting pain after shingles (called postherpetic neuralgia). It compares the real treatment to a sham (inactive) procedure to see if it truly reduces pain.
This trial compares two procedures—a nerve block injection and a radiofrequency treatment—to see which works better for lasting pain after shingles. It aims to help people with persistent pain in the neck, chest, or lower back.
This study tests a safe, non-surgical treatment called transcutaneous pulsed radiofrequency to see if it can help reduce nerve pain that continues after shingles. It targets the painful area through pads on the skin.
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