Esketamine spray plus nerve treatment for shingles pain
Part of Brain & nervous system, Pain clinical trials.
This study tests a combination of a nasal spray medicine (esketamine) and a minimally invasive procedure (pulsed radiofrequency treatment of the nerve root) to treat long-lasting pain from shingles (postherpetic neuralgia). It is for adults with moderate to severe pain that has persisted for more than 3 months.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- The pain from your shingles rash has lasted for more than 3 months.
- The shingles rash was on one side of your body (neck, chest, back, or lower back).
- Your average pain level is at least 4 on a 0–10 scale.
- You do not have sleep apnea, a history of certain severe health conditions, or drug abuse.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether adding esketamine to two standard pain medicines (pregabalin and duloxetine) can better treat nerve pain from shingles that persists for months. It's for people whose pain hasn't improved enough with pregabalin alone.
This study tests a treatment called peripheral nerve stimulation (using a small device to send mild electrical pulses) for people with nerve pain after shingles. It's designed for those whose pain is not well managed by usual treatments.
This study tests a non-invasive brain stimulation treatment for people with long-term nerve pain after shingles (postherpetic neuralgia). It compares real stimulation to a placebo to see if it reduces pain.
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This trial tests whether a gentle form of acupuncture (superficial needling with electroacupuncture) can relieve long-lasting nerve pain after shingles on the head and face. It may help if you have had head or face shingles and the pain has continued for a month or more.
This study tests a combination of a nasal spray medicine (esketamine) and a nerve treatment (pulsed radiofrequency) to reduce severe shingles pain. It may help people who have had shingles pain for less than 3 months and are already scheduled for the nerve procedure.
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