Knee osteoarthritis pain study: comparing a new injection to placebo
Part of Bones, joints & muscles clinical trials.
This phase 3 study tests whether a medicine called pentosan polysulfate sodium (PPS), given as a shot under the skin, reduces pain in people with knee osteoarthritis. It compares PPS to a placebo (a shot with no active medicine) to see if it is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have knee osteoarthritis confirmed by X-ray (Kellgren-Lawrence grade 2, 3, or 4).
- Your knee pain has not improved with at least two different treatments in the past year (for example, exercise or physical therapy plus anti-inflammatory drugs or steroid injections).
- You rate your average knee pain as 4 to 9 on a 0-to-10 scale (moderate to severe).
- Your body mass index (BMI) is between 18 and 39.
- You are willing to stop most pain medications (except a simple rescue medicine like Tylenol) for the study period.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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