Vaccine treatment for knee osteoarthritis pain
Part of Bones, joints & muscles clinical trials.
This study tests a new vaccine (PPV-06) for people with painful knee osteoarthritis that hasn't been helped by standard treatments. The vaccine is designed to reduce inflammation in the knee, which could ease pain and improve function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 40 years of age or older.
- Your body mass index (BMI) must be between 22 and 35 (a measure of weight relative to height).
- You must have a diagnosis of knee osteoarthritis with moderate joint changes, confirmed by both X-ray and MRI.
- You must have knee pain on most days during the past month, and usual pain medicines or other treatments have not helped enough.
- You must be willing to stop all pain medications for arthritis during the study (except a rescue medicine like Tylenol).
- You cannot have had certain knee injections (like steroids or lubricants) in the past month, or platelet-rich plasma (PRP) in the past 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new knee injection called CCoat to see if it can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis. If you have knee pain and some stiffness or swelling, this treatment might help you.
This study tests whether platelet-rich plasma (a treatment made from your own blood) can reduce symptoms of knee osteoarthritis. It focuses on people with specific types of knee pain and X-ray findings, and compares against rules around current pain medicines and injections.
This study tests an experimental injection called GNSC-001 given directly into the knee to see if it can reduce pain and improve knee function in people with knee osteoarthritis. If you join, you'll have one injection and then be followed for a year, and you'll need to stop your usual knee pain medicines during the study.
This study tests a new injection for knee osteoarthritis that aims to improve pain and function. It may help if you have moderate to severe knee pain that hasn't been relieved by first-line treatments.
This trial tests an injection called PTP-001 (MOTYS) for people with mild to moderate knee osteoarthritis. It aims to see if the injection can reduce knee pain and improve function.
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Hear when a new Osteoarthritis, Knee trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.