DMT with propofol for depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether a combination of DMT (a psychedelic) and propofol (a sedative) can help treat depression. You will receive both medicines in a hospital setting, and the team will monitor your response.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with moderate or severe depression (score of 20 or more on a depression scale).
- You either do not take antidepressants or have been on a stable dose for at least 4 weeks.
- You are 21 years or older.
- You understand German well enough to follow instructions and give consent.
- You agree not to drive or use heavy machinery on treatment day.
- You are willing to limit alcohol, cigarettes, and coffee, and avoid all illegal drugs during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether combining psilocybin (a psychedelic substance) with pimavanserin (a medication that may help reduce side effects) works better than psilocybin alone for treating major depressive disorder. It may help people who have not responded well to other treatments.
This study tests whether a single dose of psilocybin (a psychedelic compound) can help treat depression by looking at brain changes on MRI. It is designed for people with moderate-to-severe depression who have not responded well to other treatments.
This trial tests whether a single dose of psilocybin can help people with treatment-resistant depression by changing how they focus on themselves. It aims to understand how psilocybin affects brain activity and self-related thinking.
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
This trial tests if inhaling DMT can help treat moderate to severe major depression. You may qualify if your depression has lasted at least two weeks and you have not changed medications recently.
This trial studies the safety and effects of DMT, a psychedelic compound, in healthy volunteers and people with major depressive disorder (MDD) who haven't responded well to antidepressants. It aims to see how DMT affects the brain and mood.
Hear when a new Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.