Psilocybin with or without pimavanserin for depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether combining psilocybin (a psychedelic substance) with pimavanserin (a medication that may help reduce side effects) works better than psilocybin alone for treating major depressive disorder. It may help people who have not responded well to other treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 21 and 80 years old.
- You must have a current diagnosis of major depressive disorder (without a history of psychosis or bipolar disorder).
- You must be willing to stop taking certain antidepressants or other serotonergic medications for at least 2 weeks before the study starts.
- You cannot have used any psychedelic drugs (like LSD, psilocybin, or MDMA) in the past 12 months.
- You cannot have a significant medical condition, such as heart problems, unstable health issues, or a history of substance use disorder in the last 6 months (excluding tobacco).
- You cannot be pregnant, breastfeeding, or planning to become pregnant during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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