Entacapone with Madopar for early Parkinson's
Part of Brain & nervous system clinical trials.
This study tests whether adding entacapone to Madopar (a common Parkinson's medication) safely improves symptoms in people with early-stage Parkinson's. It aims to see if the combination works better than Madopar alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have early-stage Parkinson's (Hoehn and Yahr stage 1 to 2.5) and a specialist confirmed the diagnosis.
- You either have never taken levodopa, or you take a steady dose of 300-600 mg per day for at least a month.
- You have not used entacapone or tolcapone before (or for more than 30 days in the past).
- Your thinking skills (assessed by an MMSE test) are good (score 26 or higher).
- You do not have depression that is moderate to severe (BDI score under 15).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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