Amantadine for motor fluctuations in advanced Parkinson's disease
Part of Brain & nervous system clinical trials.
This trial tests whether adding amantadine to usual Parkinson's medications can reduce the 'off' periods when symptoms return and movement becomes harder. It is for people with advanced Parkinson's who still have daily off periods despite their current treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had Parkinson's disease for at least 3 years and are aged 30 to 80.
- You have motor fluctuations (off periods) for at least 4 weeks, with at least 2 hours of total awake time per day in the off state, including morning akinesia.
- You have never taken amantadine before.
- Your current Parkinson's medications must have been stable for at least 4 weeks before the study starts.
- You are not taking any of the excluded advanced treatments (like apomorphine pump, deep brain stimulation, or levodopa-carbidopa intestinal gel).
- You do not have severe cognitive problems (MMSE score of 26 or higher).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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