Vasopressin vs. Noradrenaline for low blood pressure after heart surgery
Treatments studied
Part of Heart & circulation clinical trials.
This trial compares two medications, vasopressin and noradrenaline, to see which one works better at raising blood pressure in patients who develop dangerously low blood pressure (vasoplegic syndrome) within the first day after heart surgery. The goal is to find the safest and most effective treatment to stabilize blood pressure and help recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had heart surgery (bypass, valve repair, or both) in the last 24 hours.
- You have very low blood pressure (below 65 mmHg) that does not improve after getting at least 1000 ml of fluids through an IV.
- You are not pregnant or breastfeeding.
- You did not have emergency surgery or heart transplant surgery.
- You do not have a history of certain conditions like Raynaud's disease or cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether vasopressin (a medication that tightens blood vessels) works better than norepinephrine for managing blood pressure after pulmonary endarterectomy surgery, which removes blood clots from the lungs. The goal is to find the safest, most effective blood-pressure support during recovery.
This trial tests whether noradrenaline is better than standard care for preventing dangerously low blood pressure during surgery. If you are having non-cardiac surgery that lasts at least an hour and are expected to stay overnight, this study may be for you.
This study tests a method to safely reduce (wean) norepinephrine, a blood-pressure–support medicine, in people who develop low blood pressure after heart surgery. It uses a monitoring index to help decide when it may be safer to lower the dose, aiming to improve recovery and reduce risks.
This study tests whether a drug called norepinephrine can safely treat a drop in blood pressure that can happen during general anesthesia in people with chronic heart failure. It focuses on patients whose heart's pumping ability is weakened (ejection fraction 40% or less) and who are having planned surgery.
This trial tests if starting Angiotensin II early, instead of other blood pressure medications, can help heart surgery patients maintain safe blood pressure. It may be an option if you have low blood pressure after surgery despite receiving fluids.
This study compares two medications given during surgery to see which one better protects the kidneys after the procedure. If you are having major non-cardiac surgery that lasts at least 2 hours and you need medication to support your blood pressure, this trial may be a good fit.
Hear when a new Vasoplegic Syndrome of Cardiac Surgery trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.