Testing a faster method to find cancer in sentinel lymph nodes
Part of Cancer, Women’s health & pregnancy clinical trials.
This trial compares a fast lab test (OSNA) with standard microscope checks to see which better finds cancer in the first lymph node (sentinel node) during surgery for early-stage endometrial cancer. It aims to improve accuracy and speed while avoiding unnecessary lymph node removal.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have endometrial cancer confirmed by a biopsy.
- Your cancer is early stage (stage I or II) before surgery.
- You are scheduled for radical surgery to remove the uterus, and your surgeon will try to find sentinel lymph nodes.
- Your cancer is not a sarcoma or a rare type like dedifferentiated or undifferentiated.
- You have not had chemotherapy or radiation before surgery, or any prior pelvic lymph node surgery.
- Your lymph nodes seen on scans are not larger than 15 millimeters.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial studies whether very small deposits of cancer (called micrometastasis or isolated tumor cells) are found in sentinel lymph nodes in early endometrial or cervical cancer. The goal is to better understand what these findings may mean for cancer spread and treatment planning.
This study compares two ways to check lymph nodes during surgery for early-stage endometrial (uterine) cancer: sentinel node biopsy versus removing more lymph nodes. It may help find whether the less extensive approach can stage the cancer accurately with fewer side effects.
This trial compares two ways to remove lymph nodes during hysterectomy for endometrial cancer that hasn't spread. The goal is to find which method works better with similar or fewer side effects.
This trial compares two ways of removing lymph nodes during a vaginal minimally invasive surgery for early-stage endometrial cancer. It aims to find which method is safer and more effective.
This study compares two ways of removing lymph nodes during surgery for a high-risk type of uterine (endometrial) cancer with a p53 gene mutation. You would be randomly assigned to either removing only the sentinel (first few) lymph nodes or removing many lymph nodes, to see if the less invasive approach is just as good.
This study compares two minimally invasive surgery methods for endometrial cancer: traditional laparoscopy (small cuts in the belly) and vNOTES (surgery through the vagina). Both use a sentinel lymph node biopsy to check if cancer has spread, and the goal is to see which approach works better.
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