Comparing Two Water Pills for Fluid Buildup in Cirrhosis
Treatments studied
Part of Digestive system clinical trials.
This trial compares two water pills (bumetanide and furosemide) in people with liver cirrhosis who need treatment for swelling from fluid buildup. It aims to see which medicine works better and is safer when started right after coming to the hospital.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with liver cirrhosis.
- Within 24 hours of coming to the hospital, your doctor ordered one of these water pills (bumetanide or furosemide).
- You are not allergic to bumetanide or furosemide.
- You don't have a reason to avoid diuretics, like active bleeding, signs of kidney problems, or low blood pressure.
- The diuretic is being given to treat swelling from fluid buildup, not for another reason.
- You are being admitted to a hospital bed after the emergency room.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether giving albumin (a protein) along with water pills helps reduce leg swelling in people with cirrhosis and ascites. It may be an option if your leg swelling hasn't improved with standard diuretics alone.
This trial compares two different water pills (acetazolamide and metolazone) added to standard treatment to help remove excess fluid in people hospitalized with acute heart failure. The goal is to find which works better to ease symptoms and improve recovery.
This study tests a medicine called rhBNP (a type of heart hormone) to help people who still have too much fluid in their body after heart surgery, even when water pills (diuretics) are not working well. The goal is to see if it helps the kidneys remove more fluid and improve recovery.
This Phase 1 study looks at why “water pills” (diuretics) like bumetanide may not remove fluid as expected in people with heart failure. The results may help clinicians improve treatment strategies for fluid control in the future.
This trial tests whether using belly pressure and bedside ultrasound can help doctors better manage fluid removal (decongestion) in people hospitalized with heart failure. The goal is to see if this approach leads to better outcomes.
This Phase 1 study looks at why “water pills” sometimes stop relieving fluid overload in people with heart failure. It may help researchers understand the causes of diuretic resistance and improve future treatment for fluid management.
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